21 Oct 2020

War Games with COVID19

The vaccine to end all vaccines, or something like that, could start rolling out for the public-at-large in just a matter of months. This could be seen to bring relief ... fingers-crossed …  from becoming an inadvertent host to this coronavirus. 

Yet, it will be more appropriate if the vaccine is not perceived as a personal condom to safeguard selected individuals from COVID19, but is seen as the mainstay of a program to eradicate the virus.

There is a fine distinction between a personal prophylactic against disease and achieving population scale immunity to stop the spread of a disease. Enmasse, entire populations or around 65 to 75 per cent as the scientists tell, must be inoculated (and in quick-time) to rid us of COVID19. 

The real aim of the vaccination program would be to safely effect the needed herd immunity to halt the virus’s spread. It means coordinating vaccinations at large scale and with a plan to spread the vaccine much faster than the virus can.

Just when the pandemic took centre-stage and even before the first lockdown in India, this article on preparing to deliver the vaccine had mooted that we approach the inoculation exercise like we address nationwide elections. For elections, booths are set-up across the country so that not a single eligible voter is left without the opportunity; in India, the entire nation is covered in phases and within months. The COVID19 vaccination program would also need to be conducted along similar lines - the key agenda being, to follow a predetermined timeline for complete geographical coverage, with no person left without. In this case, the result to count upon is the ousting of the viral spread.

Suppose the approach adopted is different, to administer the vaccine widely but to a very small category of the population (the first responders & essential workers). While these recipients will get protected, it may beget a bigger and more dangerous risk. These small number of protected individuals, scattered piecemeal amongst the rest of the population, would still come in contact with the virus and function to expose it to the effects of the vaccine... while millions of the unprotected populace still remain available as hosts.

In turn, this poses the risk of triggering an aggravated sequence of mutations in the coronavirus. This virus could then mutate to find a breach in the barriers it encounters. 

This coronavirus has already mutated more than 300 times in less than a year. Reports indicate that these mutations have not undermined the vaccines under development, so far. The biggest fear is that the vaccine may prove ineffective against a future strain of the the virus. It is therefore important that to have a fighting chance against this pandemic, the vaccine deployment be extensive and expansive. The vaccine has to be strategically used, as a weapon of mass destruction against COVID19, and not merely like a bullet proof jacket for some.

The strategy behind any COVID19 eradication program, requires adopting tactics where the vaccine is deployed like a cluster bomb. Pick up a geography, vaccinate 65 to 70 per cent of the population post-haste, shift to the next region, repeat until the whole country is done. India could conduct this simultaneously in multiple blocks, until entire districts and states achieve herd immunity by way of vaccination. This can be achieved within weeks, like we ably demonstrate during national elections, while maintaining strict anti-covid protocols.

The protection from the vaccine will kick-in after a couple of days, and even after, those protected must not travel out into non-vaccinated regions – minimise exposing the virus to those vaccinated, where it still has other viable hosts to mutate and play its own war games. A partial vaccination program where many more unvaccinated hosts remain available to the virus, or allowing the vaccinated free travel into a viral area may lead to the failure of the new vaccine and then require another round of development.
Vaccine coverage of 65 per cent of a population will rid it of this virus. Then, unable to find sufficient hosts to reproduce and spread, the 'R naught' will drop close to zero.

In India, the magic ratio of 65 amounts to around 880 million people – this is not unsurmountable for India, a country that holds national elections that caters for more than 900 million voters. However, just freeing a sub-continent from the spread of COVID19 will not be sufficient, until all the continents are equally free. Hopefully, the rest of the world will also pursue a mass cluster-based vaccination approach.
International effort to spread the vaccine faster than the coronavirus is needed. 
To understand some more about administering the vaccine to a population cluster, in full and in time, let us work backwards with a few assumptions. A vaccine giver could administer a dose every five minutes and work 10 hours a day; then, s/he can inoculate 120 others every day. Two givers per vaccination site can serve 5000 people in 21 days. 

This example means, that Delhi with 20 million residents will require 4000 vaccination sites if the exercise is to be completed in 3 weeks. These sites cannot be the hospitals as they are still overloaded with the pandemic work load. Instead, empty movie halls, schools, malls, even local pizzerias or pharmaceutical shops can be enlisted for the purpose. More such possibilities are also suggested in another article. More the number of dispersed sites, the better, to avoid crowding... and that is still a big NO NO! Going to get a vaccine should not result in coming back with the virus.

To organise the schedule, each person in the target population can receive an appointment which they could confirm by making an online payment. If they abide with the schedule, this money (or a share) can be refunded in full. But if they ignore and crowd in before their due date, then the deposit will not be refunded. This could help coerce some smidgen of discipline and prevent unplanned crowding, while easing a bit of the cash flow for the exchequer. It is here, that the high risk individuals within the target region can be allocated priority, since the entire cluster will be vaccinated in a short while in any case.

The vaccine logistics system will need to monitor the vials all through their transit until it is dosed. The key aspects will be temperature-time-shock while in transit, besides the usual batch details - any exposure to inclement conditions and impact damage should be captured at each step where the vaccine exchanges custody. There are enough sensors and loggers that the blockchain can use for such record-keeping. 

To build in systemic checks, these ledgers could also match doses administered with the usage of syringes, swabs, any diluents, etc. A planned reverse logistics of medical waste for disposal will also benefit from such records.

A lot of talk has surfaced, in my opinion wrongly conceived, on creating more dedicated cold stores and reefer vehicles for moving the primary movement of vaccines. Those suggesting will find it handy to review the involved capacities. WHO has guidelines on vaccine packaging and storage, and a handbook to calculate the amount of space required for vaccines.

Extracts from WHO guidelines and handbook

In the case of this vaccine let us assume that each dose is 0.5 ml and assess some of the logistics requirements. A cubic metre of space equals 1 million millilitres or can hold 2 million doses. However, the vaccine will not come in large casks but in small vials, maybe 4 doses to each and in secondary packaging.

Let us continue with the example of 4 doses per 2 ml vial and assume each vial of the coronavirus vaccine will occupy 20 ml (twenty cubic cms) of space in the cold-chain. A twenty footer reefer container has capacity of 28 cum and it can transport 5.6 million packaged doses. Less than 4 such reefer containers can hold the supply of 20 million doses for all of Delhi. Around 250 such containers to supply 1.35 billion doses. Around 250 such containers to supply 1.35 billion doses, which will require a total space of 6750 cubic metres - a foot print of 3688 square metres if stowed up to a height of 6 feet.

Even if each dose is 1 ml, twice the initial assumption of 0.5 ml, then these numbers will double, or could even be quadrupled. But then, the supply will not be all at once, but staggered to match production capacity. 

So, space is not a problem for bulk haulage or in storage. The real concern is after breaking bulk at the receiving depots. The situation can vary in different geographies (about 140 countries have a population of less than 20 million, with around 70 with less than 5 million).

If the vial size and packaging is designed to suit the scale of operations, then the space can be optimised. In the current scenario, as long as daily demand is assured, the supply could actually be done in much larger doses per vial, say 50 or more and in optimally designed packaging. It could make logistics more efficient and add to overall economics - though the risk also increases. Rest assured, the complexity in first- and mid-mile logistics can be handled provided the exercise is planned well in advance. In all, the primary supply and storage at vaccine depots requires very little capacities. Disposable syringes and other supplies will be the items that will actually take up more volume in transport and storage, but these should be manageable outside the cold-chain.

The real supply chain challenge, especially in a country the size of India, will be the last-mile delivery and ensuring a vaccine holding system at each vaccination site. These can be passive or active cooled technologies, or a combination thereof. It is here, where much detailing of implementation and planning is needed, to match the manufacturing capacity of the vaccine maker. If the program is undertaken in phases to achieve cluster based coverage like during elections, the last-mile equipment could also be migrated to other locations as the activity progresses. In regions where temperatures fall below 2° Celsius, the store may require heating.

Such plans will also need to be oriented to suit the supply chain model – whether the vaccine supply and medical waste pickup will be every second day, or weekly, etc. The type of vaccine, temperature required and holding life are other factors. Further details and discussions will only lengthen this post even more; and I already wonder how many had the patience to even read this one, and so far along. 

Meanwhile, we must trust the planners who are tasked this job and keep warding off the virus as best we can. Hope the virus will stay vulnerable to the vaccine... I’m also wishing that this damn virus will take a right turn to mutate into a friendly benign form.

Until then, keep safe – stay clear of crowds, wear a mask, keep clean.

PS- the above largely relates to vaccine types in -20° or 2° to 8° Celsius range. The projected production data of the vaccine wanting cryogenic care, indicates volumes that primarily targets demand from North America and Europe. That -70°C vaccine will require many thousands of specialised insulated boxes with dry ice capability, from vaccine manufacturer until terminal depots. Even then, the last stage at vaccinators site will be under the 2-8°C range. Luckily, such insulated boxes can also double to service the needs at these higher temperature ranges.

14 Apr 2020

Start-up Rural India, after Covid19

Most of rural India witnessed an unseasonal reverse migration of its able bodied manpower, who had to return perforce fearing prolonged economic duress. In the backdrop of the Covid19 pandemic, this movement from urban centres to home villages, was undertaken in defiance of a nationwide curfew. 

As this virus spreads its reach, it is quite evident that the risk of disease is heightened in localities with a high population density. When working in cities, these workers (termed migrants), tolerated crowded and squalid living conditions, usually in illegally built building blocks and slum areas that do not even pretend to have basic norms. Typically employing themselves in blue collar jobs and semi-skilled tasks, often as informal labourers, this workforce by now would understand that they are safer in the more open expanses of rural India.

8 Apr 2020

Computing a Graded Exit from Covid19 Lockdown

The Covid-19 lockdown required a cessation of all non-essential physical interaction, so as to minimise the transmission of the novel coronavirus between humans. 

Governments all over, want to curtail the rampant spread and recurrence of the virus that mainly transfers via respiratory droplets, needing physical proximity between its victims. Indirect transmission, by way of fomites, is not fully documented but any community spread would mean as much. A graded ending of the lockdown is needed.

6 Apr 2020

Covid19 Safety for Agri-markets in India

Life can only be sustained with food, and food supply is dependent on agricultural trade, which is routed through wholesale markets (mandis).

Typically, the operations in mandis involves crowds and close quarters working practices. This, in the age of COVID-19 raises some concerns. Yet, the mandis must function to maintain supply of agri-produce.

To keep the agri-markets safe, a few basic suggestions are listed. If readers have other ideas, please feel free to add in comments.

5 Apr 2020

What Next, after India's Lockdown Ends!

India’s country-wide lockdown is to end in 10 days. There are some who prefer to err on the safer side and suggest the special curfew be extended, while others hope the inconvenience be ended once and for all.

The 21-day lockdown period (from March 25) is a week longer than the recommended 14 days for isolating infected individuals; presumably, the government had taken cognisance of the possibility that the first week would see non-compliance and disruptions before the larger population would settle down and observe the restrictions in the subsequent two weeks.

27 Mar 2020

Lessons from Coronavirus could help Reform Humankind

The COVID-19 virus is a tough story to wrap your head around and so many questions are asked. Where and why did it originate, how did it turn pandemic, are we over-reacting, why is it so much more dangerous than tuberculosis, which is an ongoing pandemic and still kills 1.5 million each year.

The one clear take is that this new virus and the panic-demic, has spread like wildfire thanks to a dense and interconnected world. Budget airlines hastened its reach, and modern day social & electronic media were prompt in spreading its infamy. And our human world is still shaking, hard !